Research Focus: MPI-CBG
We study how single cells self-organize as a community to generate an organ, using the pancreas as a model. To do so, we developed 3D in vitro “organoid” culture systems modelling development, mouse genetics and live imaging in 3D. We recently developed in vitro models to also investigate this in human. These studies are intended to gain insight into human syndromes impairing pancreas development and they guide the generation of replacement beta cells for Diabetes therapy. The development of in vitro organoid models that recapitulate aspects of organogenesis in vitro Using this models in a systems biology approach to understand self-organization, as well as how interactions between physical and biochemical cues control morphogenesis and differentiation Using these models to understand how genes expressed during development predispose the fetus to subsequent development of diseases, notably diabetes. Organoids and pluripotent stem cell models Live imaging and quantitative analysis of im
Research Focus: MPI-CBG EN DE We study how single cells self-organize as a community to generate an organ, using the pancreas as a model. To do so, we developed 3D in vitro “organoid” culture systems modelling development, mouse genetics and live imaging in 3D. We recently developed in vitro models to also investigate this in human. These studies are intended to gain insight into human syndromes impairing pancreas development and they guide the generation of replacement beta cells for Diabetes therapy. The development of in vitro organoid models that recapitulate aspects of organogenesis in vi
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