Biomolecular Design

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We develop software permitting robust rational design of such molecules. The chemical building blocks that we are most interested in, and from which chemists can synthesize new molecules, include amino acids with exotic side chains, mirror-image D-amino acids, β- and γ- amino acids, peptoids and more exotic polymer building blocks. Our interests include the rational design of peptide macrocycle drugs able to bind to targets of therapeutic interest, the robust engineering of new enzymes able to catalyze chemical reactions of industrial or medicinal use, and the creation of new nanomaterials with exotic properties. We are also greatly interested in harnessing new and emerging computational technologies, such as GPUs, FPGAs, quantum computers and deep neural networks, to further advance physics-based heteropolymer design methods. Coiled-coil protein motifs have become widely employed in the design of biomaterials. Some of these designs have been studied for… Short interfering RNA (siRNA)

Biomolecular Design You are using an outdated browser. Please upgrade your browser to improve your experience. CCB CCB Home Flatiron Institute Center for Computational Biology The theory of protein folding explains how a disordered chain of amino acids spontaneously adopts a well-defined three-dimensional structure in water. The ultimate test of a theory is its successful application to the design of new physical systems with new, desired properties. In the Biomolecular Design Group, we apply the theory of protein folding to design new heteropolymers that fold into well-defined three-dimension

Biomolecular Design

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