SIFT web server: predicting effects of amino acid substitutions on proteins

The Sorting Intolerant from Tolerant (SIFT) algorithm predicts the effect of coding variants on protein function. It was first introduced in 2001, with a corresponding website that provides users with predictions on their variants. Since its release, ...

Nucleic Acids Res . 2012 Jun 9;40(Web Server issue):W452–W457. doi: 10.1093/nar/gks539 SIFT web server: predicting effects of amino acid substitutions on proteins Ngak-Leng Sim Ngak-Leng Sim 1 Computational and Systems Biology, Genome Institute of Singapore, 2 Genomic Medicine, J. Craig Venter Institute, 3 Department of Mathematics and Computer Science, Franklin & Marshall College, 4 Howard Hughes Medical Institute & Basic Sciences Division, Fred Hutchinson Cancer Research Center and 5 Biomolecular Function Discovery Division, Bioinformatics Institute of Singapore, Singapore Find articles by N

related reading

• Predicting Deleterious Amino Acid Substitutions - PMCncbi.nlm.nih.gov
• Advancing regulatory variant effect prediction with AlphaGenomenature.com
• Highly accurate protein structure prediction with AlphaFoldnature.com
• Variant effect prediction tools assessed using independent, functional assay-based datasets: implications for discovery and diagnostics | Human Genomics | Springer Nature Linkhumgenomics.biomedcentral.com
• AlphaFold2 @ CASP14: “It feels like one’s child has left home.” << Some Thoughts on a Mysterious Universemoalquraishi.wordpress.com
• A catalogue of genetic mutations to help pinpoint the cause of diseases — Google DeepMinddeepmind.google
• AlphaGenome: AI for better understanding the genome — Google DeepMinddeepmind.google
• Publications - Debbie Marks Labdeboramarkslab.com
• Protein World Model | Biohubbiohub.ai
• GitHub - Illumina/SpliceAI: A deep learning-based tool to identify splice variantsgithub.com
• AlphaFolddeepmind.google
• Google DeepMind and Isomorphic Labs introduce AlphaFold 3 AI modelblog.google