Biomolecules: the building blocks of engrams

In this essay we sketch out a bottom-up approach to investigate the building blocks of engrams. We quickly move beyond coherent quantum states and atom variations to get to the level of the biomolecule. Biomolecules can be thought of as having three main features: composition, location, and conformation. To sufficiently describe engrams, the information content of biomolecular composition and location are most likely necessary to preserve at some level of precision. On the other hand, it seems likely that bimolecular conformation can be inferred. The most important aspect of whether biomolecules are important for rapid long-term memory recall is likely whether they function in rapid electrochemical signaling across brain regions. While a bottom-up approach to engram information alone does not answer much about how engrams are stored in the brain, it is a helpful step to narrow down the possible ways that engrams could be stored in the brain before the subsequent essays. All of biology

Biomolecules: the building blocks of engrams Biomolecules: the building blocks of engrams By: Andrew McKenzie; Last Major Update: 2022-01-31; Status: Draft Summary Quantum states and atoms Molecules Anchored vs non-anchored biomolecules Biomolecular features Biomolecular composition Biomolecular location Biomolecular conformation Abstract structural features composed of biomolecules The information content of biomolecules and abstract structural features for engrams can be predicted based on their functions Summary of bottom-up approach to engram information Endnotes How lipid biomolecules in

related reading

• Engram (neuropsychology) - Wikipediaen.wikipedia.org
• Using Interpretability to Identify a Novel Class of Alzheimer's Biomarkersgoodfire.ai
• Engram neurons: Encoding, consolidation, retrieval, and forgetting of memorynature.com
• Mnemonic portraits for 19,023 human genes — LessWronglesswrong.com
• The Building Blocks of Interpretabilitydistill.pub
• So where are we with deep learning for biochem?ladanuzhna.xyz
• Memory Synapses Are Defined by Distinct Molecular Complexes: A Proposalfrontiersin.org
• The ML drug discovery startup trying really, really hard to not cheat (Leash Bio)owlposting.com
• Engramme – Remember Everythingengramme.com
• Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context - PMCpmc.ncbi.nlm.nih.gov
• Biomolecular condensateen.wikipedia.org
• The Illustrated AlphaFold | Elana Simonelanapearl.github.io