Ludovico Comito

Ludovico Comito's personal website

I am writing this blog post while on my way home from my first protein-design themed hackathon. Three days ago, when I first arrived in Zurich, I had no idea how it would turn out: as an ML person, I had general knowledge of protein design models but had never put it into practice on a real problem. Our team was a mix of CS and biology people, but none of us worked specifically in protein design. We still got to design the best binding protein on a real-world cancer problem. Besides sharing the technical details of the solution, I wanted to write this as a logbook on how to approach protein ha

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• Alex K. Chen

related reading

• One-shot design of functional protein binders with BindCraftnature.com
• AlphaFold2 @ CASP14: “It feels like one’s child has left home.” << Some Thoughts on a Mysterious Universemoalquraishi.wordpress.com
• Highly accurate protein structure prediction with AlphaFoldnature.com
• Engineering Plastic-Degrading Enzymes and PCSK9 Binders with Protein AI Toolsblog.latch.bio
• Teaching generative models to hallucinateblog.escalante.bio
• Minibinder design is just not that hardblog.escalante.bio
• Protein World Model | Biohubbiohub.ai
• The ML drug discovery startup trying really, really hard to not cheat (Leash Bio)owlposting.com
• AlphaProteo generates novel proteins for biology and health researchdeepmind.google
• prompts/prompts/multi_target_binder_design_prompt.md · Anthropic/claude-protein-binder-design at mainhuggingface.co
• A primer on machine learning in antibody engineeringabhishaike.com
• ~180 lines of code to win the in silico portion of the Adaptyv Nipah binding competitionblog.escalante.bio