Non-invasive cardiac pacing with image-guided focused ultrasound | Scientific Reports

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Advertisement Scientific Reports volume  6, Article number: 36534 (2016) Cite this article 4333 Accesses 15 Citations Metrics details Currently, no non-invasive cardiac pacing device acceptable for prolonged use in conscious patients exists. High Intensity Focused Ultrasound (HIFU) can be used to perform remote pacing using reversibility of electromechanical coupling of cardiomyocytes. Here we described an extracorporeal cardiac stimulation device and study its efficacy and safety. We conducted experiments ex vivo and in vivo in a large animal model (pig) to evaluate clinical potential of such a technique. The stimulation

Introduction The predominant technique for temporary cardiac pacing used in the clinical setting is invasive consisting in the insertion of intracardiac catheters. Although pacing with leads has been successfully used clinically for almost 60 years, these catheters are associated with costs (single-use devices, need of a sterile environment) and inherent risks1,2,3,4 from the nature of interventional procedure. Also long-term complications with leads are not negligible, therefore ways to stimulate the heart without leads are intensively looked for. The unique non-invasive method is the…

saved by

• Lev Chizhov

related reading

• The Forgotten Dangers of Ultrasoundweb.archive.org
• Functional Spectral Imaging by Ultrasound (FSIU): A Spectral-Theoretic Basis for Functional Ultrasoundarxiv.org
• Ultrafast ultrasound localization microscopy for deep super-resolution vascular imagingnature.com
• Transcranial ultrafast ultrasound localization microscopy of brain vasculature in patientsnature.com
• We have AE at homebrainhack.vercel.app
• An ECG biomarker for sudden cardiac death discovered with deep learningnature.com
• Ultrasound powered piezoelectric neurostimulation devices: a commentary | Bioelectronic Medicine | Springer Nature Linkbioelecmed.biomedcentral.com
• Application of Patient-Specific Computational Fluid Dynamics in Coronary and Intra-Cardiac Flow Simulations: Challenges and Opportunities - PMCncbi.nlm.nih.gov
• Acoustic neuromodulation from a basic science prospective - PMCncbi.nlm.nih.gov
• Analysis of the potential for non-invasive imaging of oxygenation at heart depth, using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT) - PMCpmc.ncbi.nlm.nih.gov
• Transcranial focused ultrasound phase correction using the hybrid angular spectrum methodnature.com
• Wearable ultrasound technology | Nature Reviews Bioengineeringnature.com