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Pancreatic debridement - UpToDate

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Pancreatic debridement Author:Thomas E Clancy, MD Section Editors:Stanley W Ashley, MDJohn R Saltzman, MD, MASGE, FACG, AGAF, FACP Deputy Editor:Wenliang Chen, MD, PhD Literature review current through: Aug 2026. This topic last updated: Jun 01, 2026. INTRODUCTION Pancreatic debridement is indicated for patients with pancreatic necrosis and progressive clinical sepsis or severely symptomatic sterile necrosis as a complication of severe acute pancreatitis [1,2]. Pancreatic and peripancreatic necrosis occurs in approximately 20 percent of patients with acute pancreatitis, as a result of…

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