Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response - PubMed

The integrated stress response (ISR) regulates protein synthesis under conditions of stress. Phosphorylation of translation initiation factor eIF2 by stress-sensing kinases converts eIF2 from substrate to competitive inhibitor of its dedicated nucleotide exchange factor, eIF2B, arresting translation …

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• Rongfei Lu

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