mRNA vaccines — a new era in vaccinology | Nature Reviews Drug Discovery

mRNA vaccines represent a promising alternative to conventional vaccine approaches, but their application has been hampered by instability and delivery issues. Here, Pardi and colleagues discuss recent advances in mRNA vaccine technology, assess mRNA vaccines currently in development for cancer and infectious diseases and consider future directions and challenges.

Download PDF Subjects Cancer Drug discovery Infectious diseases RNA vaccines Key Points Recent improvements in mRNA vaccines act to increase protein translation, modulate innate and adaptive immunogenicity and improve delivery. mRNA vaccines have elicited potent immunity against infectious disease targets in animal models of influenza virus, Zika virus, rabies virus and others, especially in recent years, using lipid-encapsulated or naked forms of sequence-optimized mRNA. Diverse approaches to mRNA cancer vaccines, including dendritic cell vaccines and various types of directly injectable mRNA

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