Precise DNA base editing using AlphaFold3-based contact modelling | Nature

ContactSeek is an AlphaFold3-driven model that can improve the precision of genome-editing tools.

Subjects Biotechnology Computational models Abstract Achieving high specificity in biochemical transformations is crucial for research and therapeutics. This is particularly important for genome editing, where enhancing tool specificity ensures effective and precise editing outcomes 1 , 2 . Current strategies are constrained by activity-specificity trade-offs, high labour intensity and low success rates 3 , 4 . Here we present ContactSeek, an artificial-intelligence-driven framework that uses AlphaFold3 (AF3)-predicted contact probability 5 to improve the specificity of genome editors. Using C

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