Cancer cells have distinct electrical properties that predict a susceptibility to lipophilic anions; a new cancer drug paradigm | bioRxiv

I use the Nernst equation, parameterised with experimental data, to predict that cancer cells will accumulate more of a lipophilic anion than normal cells. This effect is correlated to charge number. Model cancer cells accumulate *100 more of an anion, *103 more di-anion, *106 more tri-anion, *108 more tetra-anion and *1010 more penta-anion (>>1 billion times more). The trend endures, conveying even greater specificity, for higher charge numbers. This effect could be leveraged for cancer therapy. Wherein the lipophilic anion is a toxin that targets some vital cellular process, which normal and cancer cells may even share. It delivers a high, lethal dose to cancer cells but a low, safe dose to normal cells. This mathematical finding conveys the prospect of a broad, powerful new front against cancer.

Cancer cells have distinct electrical properties that predict a susceptibility to lipophilic anions; a new cancer drug paradigm | bioRxiv Skip to main content New Results Cancer cells have distinct electrical properties that predict a susceptibility to lipophilic anions; a new cancer drug paradigm Michael D. Forrest doi: https://doi.org/10.1101/035113 Michael D. Forrest Department of Computer Science, University of Warwick , Coventry, UK E-mail: BA|MA (Cantab), MSc, PhD Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: mikefor

related reading

• Why cancer cells have a more hyperpolarised mitochondrial membrane potential and emergent prospects for therapy | bioRxivbiorxiv.org
• A simple algebraic cancer equation: calculating how cancers may arise with normal mutation ratesbmccancer.biomedcentral.com
• Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variablespmc.ncbi.nlm.nih.gov
• ncponc_2005_169.inddbrb.nci.nih.gov
• Summing up cancer stem cellsnature.com
• diffuse.onediffuse.one
• Mutational interactions define novel cancer subgroupsnature.com
• Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma modelpmc.ncbi.nlm.nih.gov
• Application-driven design of non-aqueous electrolyte solutions through quantification of interfacial reactions in lithium metal batteries | Nature Nanotechnologynature.com
• Understanding the Material Science of Battery We Use Everydaytsijournals.com
• Epigenetic regulation during cancer transitions across 11 tumour typesnature.com
• Bioelectricitydrmichaellevin.org