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Evolutionary Scale · ESM3: Simulating 500 million years of evolution with a language model

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Update January 2025: We're thrilled to announce the publication of ESM3 in Science Magazine. We’re opening our API for biological intelligence, now in public beta, allowing scientists in academia and industry a free limited time preview of the capabilities of some of our models through Forge. More than 3.5 billion years ago, life on Earth emerged from chemical reactions. Nature invented RNA, proteins, and DNA, the core molecules of life, and created the ribosome, a molecular factory that builds proteins from instructions in the genome. Proteins are wondrous dynamic molecules with incredible functions—from molecular engines that power motion, to photosynthetic machines that capture light and convert it to energy, scaffolding that builds the internal skeletons of cells, complex sensors that interact with the environment, and information processing systems that run the programs and operating system of life. Proteins underlie disease and health, and many life-saving medicines are proteins.

Evolutionary Scale · ESM3: Simulating 500 million years of evolution with a language model By using this website, you agree to the storing of cookies on your device to analyze site usage. View our Privacy Policy for more information. Deny Accept Start working with ESM Use ESM3 June 25, 2024 // Announcement ESM3: Simulating 500 million years of evolution with a language model Preview our paper Update January 2025: We're thrilled to announce the publication of ESM3 in Science Magazine . We’re opening our API for biological intelligence, now in public beta, allowing scientists in academia and ind

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