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Hill equation (biochemistry) - Wikipedia

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In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration. A ligand is "a substance that forms a complex with a biomolecule to serve a biological purpose" (ligand definition), and a macromolecule is a very large molecule, such as a protein, with a complex structure of components (macromolecule definition). Protein-ligand binding typically changes the structure of the target protein, thereby changing its function in a cell. The distinction between the two Hill equations is whether they measure occupancy or response. The Hill equation reflects the occupancy of macromolecules: the fraction that is saturated or bound by the ligand.[1][2][nb 1] This equation is formally equivalent to the Langmuir isotherm.[3] Conversely, the Hill equation proper reflects the cellular or tissue response to the ligand: the physiological output of the system, such as muscle contrac

Hill equation (biochemistry) - Wikipedia Jump to content From Wikipedia, the free encyclopedia Diagram showing the proportion of a receptor bound to a ligand This article is about the Hill equation as an equation used in biochemical characterization. For other uses, see Hill differential equation . Binding curves showing the characteristically sigmoidal curves generated by using the Hill equation to model cooperative binding. Each curve corresponds to a different Hill coefficient, labeled to the curve's right. The vertical axis displays the proportion of the total number of receptors that have

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