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Orexin - Wikipedia

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Orexin (/ɒˈrɛksɪn/), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite.[5] It exists in the forms of orexin-A and orexin-B. The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells that produce it.[6][7] There are 50,000–80,000 orexin-producing neurons in the human brain,[8] located predominantly in the perifornical area and lateral hypothalamus.[5][9] They project widely throughout the central nervous system, regulating wakefulness, feeding, and other behaviours.[5] There are two types of orexin peptide and two types of orexin receptor.[10][9] Orexin was discovered in 1998 almost simultaneously by two independent groups of researchers working on the rat brain.[11][12][13] One group named it orexin, from orexis, meaning "appetite" in Greek; the other group named it hypocretin, because it

Orexin - Wikipedia Jump to content From Wikipedia, the free encyclopedia Neuropeptide that regulates arousal, wakefulness, and appetite HCRT Identifiers Aliases HCRT , OX, PPOX, hypocretin neuropeptide precursor, NRCLP1 External IDs OMIM : 602358 ; MGI : 1202306 ; HomoloGene : 1166 ; GeneCards : HCRT ; OMA : HCRT - orthologs Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CQ0 , 1WSO , 1UVQ , 1R02 Gene location ( Human ) Chr. Chromosome 17 (human) [ 1 ] Band 17q21.2 Start 42,184,060 bp [ 1 ] End 42,185,452 bp [ 1 ] Gene location ( Mouse ) Chr. Chromosome 11 (mouse) [ 2

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