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Evo 2: DNA Foundation Model | Arc Institute

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Evo 2 is a genomic foundation model capable of generalist prediction and design tasks across DNA, RNA, and proteins. It uses a frontier deep learning architecture to enable modeling of biological sequences at single-nucleotide resolution with near-linear scaling of compute and memory relative to context length. Evo 2 is trained with 40 billion parameters and 1 megabase context length on over 9 trillion nucleotides of diverse eukaryotic and prokaryotic genomes. Evo Designer Evo Mechanistic Interpretability Visualizer Learn more about Evo

Evo 2: DNA Foundation Model | Arc Institute Evo 2: DNA Foundation Model Evo 2 is a genomic foundation model capable of generalist prediction and design tasks across DNA, RNA, and proteins. It uses a frontier deep learning architecture to enable modeling of biological sequences at single-nucleotide resolution with near-linear scaling of compute and memory relative to context length. Evo 2 is trained with 40 billion parameters and 1 megabase context length on over 9 trillion nucleotides of diverse eukaryotic and prokaryotic genomes. Evo 2 Published March 2026, Nature Evo 1 Published November 202

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