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CTCF - Wikipedia

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Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene.[5][6] CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination[7] and regulation of chromatin architecture.[8] CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus was named CCCTC binding factor.[9] The primary role of CTCF is thought to be in regulating the 3D structure of chromatin.[8] CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures like the nuclear lamina.[10] It also defines the boundaries between active and heterochromatic DNA. Since the 3D structure of DNA influences the regulation of genes, CTCF's activity influences the expression of genes. C

CTCF - Wikipedia Jump to content From Wikipedia, the free encyclopedia Transcription factor For the prison, see Colorado Territorial Correctional Facility . CTCF Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X6H , 2CT1 Identifiers Aliases CTCF , MRD21, CCCTC-binding factor, FAP108, CFAP108 External IDs OMIM : 604167 ; MGI : 109447 ; HomoloGene : 4786 ; GeneCards : CTCF ; OMA : CTCF - orthologs Gene location ( Human ) Chr. Chromosome 16 (human) [ 1 ] Band 16q22.1 Start 67,562,467 bp [ 1 ] End 67,639,177 bp [ 1 ] Gene location ( Mouse ) Chr. Ch

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