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Relevance of Simpson grading system and recurrence-free survival after surgery for World Health Organization Grade I meningioma in: Journal of Neurosurgery Volume 126 Issue 1 (2017) Journals

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OBJECTIVE The clinical significance of the Simpson system for grading the extent of meningioma resection and its role as a predictor of the recurrence of World Health Organization (WHO) Grade I meningiomas have been questioned in the past, echoing changes in meningioma surgery over the years. The authors reviewed their experience in resecting WHO Grade I meningiomas and assessed the association between extent of resection, as evaluated using the Simpson classification, and recurrence-free survival (RFS) of patients after meningioma surgery. METHODS Clinical and radiological information for patients with WHO Grade I meningiomas who had undergone resective surgery over the past 20 years was retrospectively reviewed. Simpson and Shinshu grading scales were used to evaluate the extent of resection. Statistical analysis was conducted using Kaplan-Meier curves and Cox proportional-hazards regression. RESULTS Four hundred fifty-eight patients were eligible for analysis. Overall tumor recurrence rates for Simpson resection Grades I, II, III, and IV were 5%, 22%, 31%, and 35%, respectively. After Cox regression analysis, Simpson Grade I (extensive resection) was revealed as a significant predictor of RFS (p = 0.003). Patients undergoing Simpson Grade I and II resections showed significant improvement in RFS compared with patients undergoing Grade III and IV resections (p = 0.005). Extent of resection had a significant effect on recurrence rates for both skull base (p = 0.047) and convexity (p = 0.012) meningiomas. Female sex and a Karnofsky Performance Scale score > 70 were also identified as independent predictors of RFS after resection of WHO Grade I meningioma. CONCLUSIONS In this patient cohort, a significant association was noted between extent of resection and rates of tumor recurrence. In the authors' experience the Simpson grading system maintains its relevance and prognostic value and can serve an important role for patient education. Even though complete tumor resection is the goal, surgery should be tailored to each patient according to the risks and surgical morbidity.

Relevance of Simpson grading system and recurrence-free survival after surgery for World Health Organization Grade I meningioma in: Journal of Neurosurgery Volume 126 Issue 1 (2017) Journals Jump to Content This site uses cookies , tags, and tracking settings to store information that help give you the very best browsing experience. Dismiss this warning My Stuff Sign in Sign up Home COVID-19 Journals Just Published For Authors For Librarians About Us Submit Subscribe Advanced Search Help My Stuff Sign in Sign up Submit Subscribe Home COVID-19 Journals Journal of Neurosurgery Journal of Neurosu

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