Schizophrenia Drugs Are Finally Getting an Overhaul | WIRED

Current antipsychotics are plagued by patchy efficacy and unwanted side effects—but a new treatment could change all that.

Save this story Save this story On December 11, 1951, in the labs of French pharmaceutical company Rhône-Poulenc, chemist Paul Charpentier concocted a drug that would change the field of psychiatry forever. Charpentier hadn’t intended to spark a revolution; he was actually trying to make a better antihistamine. But by tweaking an existing drug called promazine, he ended up making a new compound called chlorpromazine. The drug was passed on to a surgeon by the name of Henri Laborit, who was on the hunt for a more effective anesthetic. He noticed it produced a calming effect in his patients, and

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