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Treatment-resistant depression

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Treatment-resistant depression (TRD) is a term used in clinical psychiatry to describe a condition that affects people with major depressive disorder (MDD) who do not respond adequately to a course of appropriate antidepressant medication within a certain time. Typical definitions of TRD vary, and they do not include a resistance to psychological therapies. Inadequate response has traditionally been defined as no clinical response whatsoever (e.g. no improvement in depressive symptoms). However, many clinicians consider a response inadequate if the person does not achieve full remission of symptoms. People with treatment-resistant depression who do not adequately respond to antidepressant treatment are sometimes referred to as pseudoresistant. Some factors that contribute to inadequate treatment are: early discontinuation of treatment, insufficient dosage of medication, patient noncompliance, misdiagnosis, and concurrent psychiatric disorders. Cases of treatment-resistant depression may also be referred to by which medications people with TRD are resistant to (e.g.: SSRI-resistant). In TRD adding further treatments such as psychotherapy, lithium, or aripiprazole is weakly supported as of 2019.

Treatment-resistant depression - Wikipedia Jump to content From Wikipedia, the free encyclopedia This article is written like a research paper or a scientific journal . Please help rewrite it in a neutral , encyclopedic style and simplify overly technical phrases . ( February 2026 ) Medical condition Treatment-resistant depression Other names Treatment-refractory depression Specialty Psychiatry Symptoms Depressive mood , anhedonia , low energy Complications Self-harm , suicide Treatment-resistant depression ( TRD ) is often defined as major depressive disorder in which an affected person does

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