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Volume 6, Chapter 44. Keratoprosthesis

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After 1906, when the first human-to-human corneal graft was performed, there was a loss of interest in keratoprosthesis development and surgery. In 1920, Verhoeff reported on a single case of insertion of a quartz button into a patient's cornea; however, it had to be removed shortly afterward.7 Similarly, Filatov,8 in 1935, implanted a full penetrating glass device into a patient's opacified cornea and covered it with a double conjunctival flap after surgery. He left the flap in place, and after 6 months it had thinned sufficiently to give the patient an ambulatory vision of 1/200. More details on the history of keratoprosthesis surgery around this period have been reported previously in reviews by Day,9 Cardona,10 and Lund.11 During World War II, Wunsche,12 Stone,13 and others noticed that polymethylmethacrylate (PMMA) splinters embedded in the cornea of pilots were well tolerated. This led to their experiments showing that PMMA discs could be retained in the cornea of rabbits. Soon h

Volume 6, Chapter 44. Keratoprosthesis Chapter 44 Keratoprosthesis WILLIAM J. POWER Main Menu Table Of Contents Search HISTORY KERATOPROSTHESIS DESIGN INDICATIONS SURGICAL PROCEDURE AND EARLY POSTOPERATIVE CARE COMPLICATIONS RESULTS CURRENT RESEARCH CONCLUSIONS REFERENCES Keratoprosthesis surgery is indicated in cases of corneal blindness for which penetrating keratoplasty is almost certain to fail. Such cases include ocular cicatricial pemphigoid, Stevens-Johnson syndrome, severe chemical burns, severely vascularized corneas, and recurrent graft failure. Keratoprosthesis surgery can be associ

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