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Neurotrophic Keratitis - EyeWiki

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Neurotrophic keratitis (or keratopathy) (NK) is a corneal degenerative disease characterized by a reduction or absence of corneal sensitivity. In NK, corneal innervation by the trigeminal nerve is impaired. Partial or complete loss of corneal sensation may result in epithelial keratopathy, epithelial defect, stromal ulceration, and eventually corneal perforation. The epidemiology of NK is still uncertain. As a rare disease, its estimated prevalence is less than 50/100,000 individuals.[1] Every ocular or systemic condition altering corneal sensory innervation—which runs from the cornea itself to the pontine trigeminal nucleus—can result in NK. Risk factors for NK are those related to the underlying etiology. A number of histological alterations are seen in corneas of patients with NK, including thinning/disruption of the epithelial layer, cytoplasmic swelling of epithelial cells, loss of microvilli, disorganization of Bowman’s membrane, stromal melting/scarring, and corneal neovasculari

Neurotrophic Keratitis - EyeWiki Create account Log in Page Discussion View form View source View history Neurotrophic Keratitis From EyeWiki Jump to: navigation , search All content on Eyewiki is protected by copyright law and the Terms of Service . This content may not be reproduced, copied, or put into any artificial intelligence program, including large language and generative AI models, without permission from the Academy. Article initiated by : Alessandro.Rabiolo ,  Giulio Ferrari ,  Paolo Rama All contributors: Ana Maria Cunha ,  Vatinee Y. Bunya, MD, MSCE ,  Maria

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