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PoL – Physics of Life | Research | Core Groups | Miki Ebisuya

physics-of-life.tu-dresden.de · 776 words · saved by 1 readers

Different animal species exhibit different physiological times and different forms. For example, the human gestation period is about 9 months, compared to just 20 days for mice and almost 1.5 years for rhinoceroses. How organisms achieve the time and form inherent in these species is a fundamental question in biology and biophysics, but the mechanism remains largely unknown. One of the challenges of such studies is the difficulty to perform experiments on different animals, especially living embryos – we can’t keep rhinos in the lab. Therefore, our group uses pluripotent stem cells established from various animals, or the “stem cell zoo” (Fig. 1). By letting stem cells differentiate into appropriate cell types, we can recapitulate species-specific time, or create a tissue structure that partly mimics the morphology of developing embryos. These in vitro models created from the stem cell zoo not only enable the comparison of different species in similar culture conditions, but also have

PoL – Physics of Life | Team | PoL Principal Investigators | Miki Ebisuya ul"> Jump to main navigation Jump to sub navigation Jump to content Jump to sitemap Miki Ebisuya Group Cross-Species Comparison and Manipulation of the Organoid Zoo Fig 1: The stem cell zoo in the lab. Related to Lázaro et al., Cell Stem Cell (2023). Illustration by Júlia Charles. Different animal species exhibit different physiological times and different forms. For example, the human gestation period is about 9 months, compared to just 20 days for mice and almost 1.5 years for rhinoceroses. How organisms achieve the ti

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