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SH3 domain

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The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. This domain is also present in the molecules of phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src. It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25. SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site. Approximately 300 SH3 domains are found in proteins encoded in the human genome. In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction pathways and regulating the interactions of proteins involved in the cytoplasmic signaling.

SH3 domain - Wikipedia Jump to content From Wikipedia, the free encyclopedia Small protein domain found in some kinases and GTPases Protein domain SH3 domain Ribbon diagram of the SH3 domain, alpha spectrin, from chicken (PDB accession code 1SHG), colored from blue (N-terminus) to red (C-terminus). Identifiers Symbol SH3_1 Pfam PF00018 Pfam clan CL0010 ECOD 4.1.1 InterPro IPR001452 SMART SM00326 PROSITE PS50002 SCOP2 1shf / SCOPe / SUPFAM CDD cd00174 Available protein structures: PDB   IPR001452 PF00018 ( ECOD ; PDBsum )   AlphaFold IPR001452 PF00018 The SRC Homology 3 Domain (or SH3

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