Noah Gurley : Peifer Lab

Position Post-Baccalaureate Research Assistant (2021 – Present) Education: B.Sc. in Quantitative Biology at UNC-CH (w/ a minor in Neuroscience) 2021 Email: ngurley@unc.edu Cadherin-based adherens junctions (AJs) promote coordinated behavior in epithelial cells by facilitating a connection between the apical membranes and actomyosin cytoskeletons of neighboring cells. The proper assembly, positioning, and function of AJs requires assembly of a large multiprotein machine at the apicolateral membrane, via interactions between specific domains of these proteins. Canoe (Cno) is a large scaffolding protein and is an orthologue of the mammalian protein Afadin. The full-length, wild-type Cno protein sequence contains multiple structural domains, three of which have been of particular interest to our lab in recent years; these include the Ras-associated, PDZ-binding, and filamentous actin-binding domains. Specific domains of Cno interact with junctional, cytoskeletal, and regulatory proteins;

Peifer Lab The University of North Carolina at Chapel Hill Accessibility Events Libraries Maps Departments ConnectCarolina UNC Search You are using an outdated browser. Please upgrade your browser to improve your experience. Skip to main content --> Submit Search HOME MORPHOGENESIS We use developing embryos to explore the cell biology of morphogenesis — in this gastrulating embryo, cytoskeletal (blue) and adhesion proteins (red) become reciprocally planar polarized. Cell adhesion, cytoskeletal regulation and Wnt signaling in development and disease We work at the interface between cell and dev

related reading

• Peifer Labpeiferlab.web.unc.edu
• Peifer Labpeiferlab.web.unc.edu
• Peifer Labpeiferlab.web.unc.edu
• Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton - PMCncbi.nlm.nih.gov
• Patterning and Morphogenesis From Cells to Organisms: Progress, Common Principles and New Challenges - PMCncbi.nlm.nih.gov
• Mechanosensing and Mechanotransduction at Cell–Cell Junctions - PMCncbi.nlm.nih.gov
• Roadmap for the multiscale coupling of biochemical and mechanical signals during development - IOPscienceiopscience.iop.org
• Research – MartinLabmartin-lab.mit.edu
• A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension - PMCncbi.nlm.nih.gov
• Filopodia-based contact stimulation of cell migration drives tissue morphogenesis | Nature Communicationsnature.com
• Munro Lab – University of Chicagomunrolab.uchicago.edu
• Spatial Information | Department of Biologyas.tufts.edu