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Projects | Statistical Physics in Biology | Physics | MIT OpenCourseWare

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Students can collaborate in groups provided that the respective contributions of the author of the joint paper is clearly specified in a footnote. (The length of the paper may be proportionately longer in such collaborations.) Clearly the initial hurdle is coming up with an interesting problem doable in a short time. We would thus like you to think about potential projects, and consult with Prof. Kardar or Prof. Mirny regarding their suitability (preferably as soon as possible, but no later than one day after Ses #16). Epistatic interactions between mutations: In class we described a model for the dy-namics of a single mutation (or independently evolving mutations). Generalize the description to two mutations in which the fitness of the double mutant is not simply the sum of the fitnesses for single mutants. ‘Finite temperature’ alignments: The standard tests of sequence similarity (such as BLAST) result in a score which can be interpreted as the lowest energy of a directed polymer. On

Final Project Guidelines Please choose one of the following two for a final project: Research Project: For the final project, you should write a brief paper (two to four pages in Physical Review format) about a topic of your choice at the interface of Statistical Physics and Biology. It should be formatted as a regular article with title, abstract, and bibliography. The main text should contain introductory and concluding paragraphs (whether or not they appear as subsections is not important). The ideal project will involve a combination of literature review, discussion of an analytical or com

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