✳flâneur — a map of the web's best reading

Clinical manifestations, diagnosis, and management of diabetic infections of the lower extremities - UpToDate

uptodate.com · 1 words · saved by 1 readers

INTRODUCTION Diabetic foot infections are associated with substantial morbidity and mortality [1]. Important risk factors for development of diabetic foot infections include neuropathy, peripheral vascular disease, and poor glycemic control. In the setting of sensory neuropathy, there is diminished perception of pain and temperature; thus, many patients are slow to recognize the presence of an injury to their feet. Autonomic neuropathy can cause diminished sweat secretion resulting in dry, cracked skin that facilitates the entry of microorganisms to the deeper skin structures. In addition, motor neuropathy can lead to foot deformities, which lead to pressure-induced soft tissue damage. Peripheral artery disease can impair blood flow necessary for healing of ulcers and infections. Hyperglycemia impairs neutrophil function and reduces host defenses. Trauma in patients with one or more of these risk factors precipitates development of wounds that can be slow to heal and predispose to seco

UpToDate

Explore this link on the map →

related reading