Overview of the myeloproliferative neoplasms - UpToDate
INTRODUCTION An overview of the four classic myeloproliferative neoplasms (MPN): polycythemia vera, essential thrombocythemia, primary myelofibrosis, and chronic myeloid leukemia will be presented here. Detailed information on each of these disorders is presented separately. ● (See "Clinical manifestations and diagnosis of polycythemia vera".) ● (See "Essential thrombocythemia: Treatment and prognosis".) ● (See "Clinical manifestations and diagnosis of primary myelofibrosis".) ● (See "Clinical manifestations and diagnosis of chronic myeloid leukemia".) CLASSIFICATION OF HEMATOLOGIC MALIGNANCIES The hematopoietic pluripotent stem cell is capable of both self-renewal and stepwise differentiation into either the lymphoid or myeloid lineage (which appears to be determined stochastically) [1]. Thus, during normal hematopoiesis, there exists a cellular hierarchy headed by a stable population of pluripotent stem cells that generate lineage-specific progenitors, which differentiate into the va
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