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Dyslipidemia - Endocrine and Metabolic Disorders - MSD Manual Professional Edition

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Lipids are fats that are either absorbed from food or synthesized by the liver. Triglycerides (TGs) and cholesterol contribute most to disease, although all lipids are physiologically important. Cholesterol is a ubiquitous constituent of cell membranes, steroids, bile acids, and signaling molecules. Triglycerides primarily store energy in adipocytes and muscle cells. Lipoproteins are hydrophilic, spherical structures that possess surface proteins (apoproteins, or apolipoproteins) that are cofactors and ligands for lipid-processing enzymes (see table Major Apoproteins and Enzymes Important to Lipid Metabolism). All lipids are hydrophobic and mostly insoluble in blood, so they require transport within lipoproteins. Lipoproteins are classified by size and density (defined as the ratio of lipid to protein) and are important because high levels of low-density lipoproteins (LDL) and low levels of high-density lipoproteins (HDL) are major risk factors for atherosclerotic heart disease. Dyslip

Dyslipidemia - Endocrinology - MSD Manual Professional Edition honeypot link Dyslipidemia (Hyperlipidemia) Full Review: May 2025 By Michael H. Davidson , MD, FACC, FNLA , University of Chicago Medicine, Pritzker School of Medicine | Marie Altenburg , MD , The University of Chicago | Peer reviewed by Glenn D. Braunstein , MD , Cedars-Sinai Medical Center Last updated: Apr 2026 v989684 View Patient Education Dyslipidemia is elevation of plasma cholesterol, triglycerides (TGs), or both, or a low high-density lipoprotein cholesterol (HDL-C) level that contributes to the development of atherosclero

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