Fos ensembles encode and shape stable spatial maps in the hippocampus | Nature

Fos-expressing hippocampal neurons form highly correlated ensembles that contribute to spatial coding by forming reliable, long-lasting and spatially unbiased maps of an environment.

Download PDF Subjects Hippocampus Navigation Abstract In the hippocampus, spatial maps are formed by place cells while contextual memories are thought to be encoded as engrams 1 , 2 , 3 , 4 , 5 , 6 . Engrams are typically identified by expression of the immediate early gene Fos , but little is known about the neural activity patterns that drive, and are shaped by, Fos expression in behaving animals 7 , 8 , 9 , 10 . Thus, it is unclear whether Fos-expressing hippocampal neurons also encode spatial maps and whether Fos expression correlates with and affects specific features of the place code 11

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