flâneur

Eddie Sun

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on the atlas — 53

highlights — 210

  • To better understand disease and drug targets, scientists spend much time extracting and summarizing information in documents such as patents, scientific publications, and trial data. That is not only arduous but also often provides incomplete or inaccurate information, given the sheer volume of data that must be processed. GPT-powered knowledge extraction—which uses AI algorithms to analyze unstructured data, including text, images, and other forms of information—can alleviate this burden. Unlike earlier solutions based on natural-language processing (NLP), new gen AI tools offer a much deepe…
    Generative AI in the pharmaceutical industry | McKinsey
  • One widely supported explanation is that having a greater sense of control (by setting their own schedules and determining how to tackle the challenges they face) protects them against the demands
    80K_HOURS_final.pdf
  • I DON’T SUPPORT A STRATEGIC BITCOIN RESERVE, AND NEITHER SHOULD YOU
    I don’t support a Strategic Bitcoin Reserve, and neither should you - Bitcoin Magazine - Bitcoin News, Articles and Expert Insights
  • Or perhaps what you really want is a level of security so over-the-top secure it can no longer be called a security yearning—instead, it may be an impulse by the emotional well-being section of your lifestyle tentacle to alleviate a compulsive financial stress you were raised to forever feel, almost regardless of your actual financial situation.
    How to Pick a Career (That Actually Fits You) — Wait But Why
  • There is an important discussion to be had about the long term prospects for native tokens like Bitcoin, Solana, or Ether in a world where almost all transactions on chain are settled in stables, but that is a question for the crypto-natives to grapple with.
    Five perspectives on stablecoins. Evaluating the state of the academic… | by Nic Carter | Medium
  • Decentralized-overcollateralized lending protocols produce stablecoins that are useful and reliable, but have seen flat demand.
    A useful framework for understanding stablecoins: Banking history - a16z crypto
  • While NNPs have been under development for some time,14 recent advancements in ML have significantly enhanced their practical utility. One such critical advancement is the incorporation of equivariance, which encodes the spatial symmetries of 3D space into the neural network.20−23 This feature, also pivotal in the success of AlphaFold2
    The Potential of Neural Network Potentials
  • Product: At this point, your product is likely nothing more than an idea. Spiros notes that every time he built product features based on pure speculation, it ended up being a waste of time.
    Customer validation: Going from idea to sellable product
  • An early UI/UX hire can be a critical team player to quickly iterate and confirm with customers what a sellable solution would look like.
    Customer validation: Going from idea to sellable product
  • thermal conductivity, heat capacity
    Quantum Generative Materials Achieves Breakthrough Materials Simulation
  • 50 researchers in the world that know how to build a GPT-4 or Claude 2-level system
    The Modern AI Stack: Design Principles for the Future of Enterprise AI Architectures - Menlo Ventures
  • chunk size of 1024 might strike an optimal balance between response time and the quality of the responses
    Evaluating the Ideal Chunk Size for a RAG System using LlamaIndex | by Ravi Theja | LlamaIndex Blog
  • projec- tions for dimension reduction or signal filtering
    The Little Book of Deep Learning
  • If something that seems like work to other people doesn't seem like work to you, that's something you're well suited for.
    What Doesn't Seem Like Work?
  • having new ideas is generally associated with youth. But perhaps it's not youth per se that yields new ideas, but specific things that come with youth, like good health and lack of responsibilities
    Beyond Smart
  • Imagine you had a choice between being really smart but discovering nothing new, and being less smart but discovering lots of new ideas
    Beyond Smart
  • intelligence and its consequences are not identical
    Beyond Smart
  • When you read biographies of people who've done great work, it's remarkable how much luck is involved. They discover what to work on as a result of a chance meeting, or by reading a book they happen to pick up. So you need to make yourself a big target for luck, and the way to do that is to be curious. Try lots of things, meet lots of people, read lots of books, ask lots of questions.
    How to Do Great Work
  • By compressing the dull but necessary task of making a living into the smallest possible time, you show respect for life, and there is something grand about that.
    The Hardest Lessons for Startups to Learn
  • Economically, a startup is best seen not as a way to get rich, but as a way to work faster. You have to make a living, and a startup is a way to get that done quickly, instead of letting it drag on through your whole life.
    The Hardest Lessons for Startups to Learn
  • The way to succeed in a startup is to focus on the goal of getting lots of users, and keep walking swiftly toward it while investors and acquirers scurry alongside trying to wave money in your face.
    The Hardest Lessons for Startups to Learn
  • Deals are dynamic; unless you're negotiating with someone unusually honest, there's not a single point where you shake hands and the deal's done.
    The Hardest Lessons for Startups to Learn
  • The reason I warn startups not to get their hopes up is not to save them from being disappointed when things fall through. It's for a more practical reason: to prevent them from leaning their company against something that's going to fall over, taking them with it.
    The Hardest Lessons for Startups to Learn
  • It's ok to be optimistic about what you can do, but assume the worst about machines and other people.
    The Hardest Lessons for Startups to Learn
  • You can't fake this. The only way to convince everyone that you're ready to fight to the death is actually to be ready to.
    The Hardest Lessons for Startups to Learn
  • If an acquirer thinks you're going to stick around no matter what, they'll be more likely to buy you, because if they don't and you stick around, you'll probably grow, your price will go up, and they'll be left wishing they'd bought you earlier. Ditto for investors. What really motivates investors, even big VCs, is not the hope of good returns, but the fear of missing out.
    The Hardest Lessons for Startups to Learn
  • At Y Combinator we sometimes mistakenly fund teams who have the attitude that they're going to give this startup thing a shot for three months, and if something great happens, they'll stick with it-- "something great" meaning either that someone wants to buy them or invest millions of dollars in them. But if this is your attitude, "something great" is very unlikely to happen to you, because both acquirers and investors judge you by your level of commitment.
    The Hardest Lessons for Startups to Learn
  • Everyone who deals with startups knows how important commitment is, so if they sense you're ambivalent, they won't give you much attention. If you lack commitment, you'll just find that for some mysterious reason good things happen to your competitors but not to you. If you lack commitment, it will seem to you that you're unlucky.
    The Hardest Lessons for Startups to Learn
  • Imagine if you were hired at some big company, and in addition to writing software ten times faster than you'd ever had to before, they expected you to answer support calls, administer the servers, design the web site, cold-call customers, find the company office space, and go out and get everyone lunch.
    The Hardest Lessons for Startups to Learn
  • Of course, if you want to get rich, it's not enough merely to be determined. You have to be smart too, right? I'd like to think so, but I've had an experience that convinced me otherwise: I spent several years living in New York. You can lose quite a lot in the brains department and it won't kill you. But lose even a little bit in the commitment department, and that will kill you very rapidly.
    The Hardest Lessons for Startups to Learn
  • The most important quality in a startup founder is determination. Not intelligence-- determination
    The Hardest Lessons for Startups to Learn
  • Way more startups hose themselves than get crushed by competitors. There are a lot of ways to do it, but the three main ones are internal disputes, inertia, and ignoring users.
    The Hardest Lessons for Startups to Learn
  • No matter what your idea, there's someone else out there working on the same thing.
    The Hardest Lessons for Startups to Learn
  • So who should start a startup? Someone who is a good hacker, between about 23 and 38, and who wants to solve the money problem in one shot instead of getting paid gradually over a conventional working life.
    How to Start a Startup
  • When you get a couple million dollars from a VC firm, you tend to feel rich. It's important to realize you're not. A rich company is one with large revenues. This money isn't revenue. It's money investors have given you in the hope you'll be able to generate revenues. So despite those millions in the bank, you're still poor.
    How to Start a Startup
  • There is nothing more valuable, in the early stages of a startup, than smart users. If you listen to them, they'll tell you exactly how to make a winning product. And not only will they give you this advice for free, they'll pay you.
    How to Start a Startup
  • When and if you get an infusion of real money from investors, what should you do with it? Not spend it, that's what.
    How to Start a Startup
  • And as you go down the food chain the VCs get rapidly dumber. A few steps down from the top you're basically talking to bankers who've picked up a few new vocabulary words from reading Wired.
    How to Start a Startup
  • If you want ideas for startups, one of the most valuable things you could do is find a middle-sized non-technology company and spend a couple weeks just watching what they do with computers. Most good hackers have no more idea of the horrors perpetrated in these places than rich Americans do of what goes on in Brazilian slums.
    How to Start a Startup
  • When you work on making technology easier to use, you're riding that curve up instead of down. A 10% improvement in ease of use doesn't just increase your sales 10%. It's more likely to double your sales.
    How to Start a Startup
  • A 10% improvement in ease of use doesn't just increase your sales 10%. It's more likely to double your sales.
    How to Start a Startup
  • Being friends with someone for even a couple days will tell you more than companies could ever learn in interviews.
    How to Start a Startup
  • What matters is not ideas, but the people who have them. Good people can fix bad ideas, but good ideas can't save bad people.
    How to Start a Startup
  • start with good people, to make something customers actually want, and to spend as little money as possible
    How to Start a Startup
  • If life seems awful to kids, it's neither because hormones are turning you all into monsters (as your parents believe), nor because life actually is awful (as you believe). It's because the adults, who no longer have any economic use for you, have abandoned you to spend years cooped up together with nothing real to do. Any society of that type is awful to live in. You don't have to look any further to explain why teenage kids are unhappy.
    Why Nerds are Unpopular
  • If I remember correctly, the most popular kids don't persecute nerds; they don't need to stoop to such things.
    Why Nerds are Unpopular
  • VCs' legal and financial due diligence is pretty thorough, but the technical due diligence is generally a joke.
    How to Fund a Startup
  • VCs are like high school girls: they're acutely aware of their position in the VC pecking order, and their interest in a company is a function of the interest other VCs show in it.
    How to Fund a Startup
  • The average founder is smarter than the average VC.
    How to Fund a Startup
  • I'm not hard to find. I know a lot of people. If you can't find some way to reach me, how are you going to create a successful company?
    How to Fund a Startup