flâneur

Ch Lh

1 followers · 432 views

on the atlas — 12

highlights — 57

  • "if you change the way you look at things, the things you look at change"
    Visual Intelligence | Amy Herman | Talks at Google - YouTube
  • "If you change the way you look at things, the things you look at change."
    Visual Intelligence | Amy Herman | Talks at Google - YouTube
  • "If you change the way you look at things, the things you look at change."
    Visual Intelligence | Amy Herman | Talks at Google - YouTube
  • hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication
    The Hallmarks of Aging
  • the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution
    The Hallmarks of Aging
  • Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death.
    The Hallmarks of Aging
  • Genomic instability Telomere attrition Epigenetic alterations Loss of proteostasis Deregulated nutrient-sensing Mitochondrial dysfunction Cellular senescence Stem cell exhaustion Altered intercellular communication
    Anti-Aging: State of the Art - LessWrong
  • This 'damage' associated with aging comes in essentially 9 forms, known as the hallmarks of aging: Genomic instability Telomere attrition Epigenetic alterations Loss of proteostasis Deregulated nutrient-sensing Mitochondrial dysfunction Cellular senescence Stem cell exhaustion Altered intercellular communication
    Anti-Aging: State of the Art - LessWrong
  • Aging is essentially damage that accumulates over time, which exponentially increases the risk of the diseases that kill most people
    Anti-Aging: State of the Art - LessWrong
  • What’s up with our memory of dreams?
    Research Ideas
  • Do people have different levels of self-control or do they just experience temptation differently?
    Research Ideas
  • How does mental imagery work? How do we improve its function?
    Research Ideas
  • Does poor eyesight make you smarter?
    Research Ideas
  • We invest an enormous amount of time and money in science. Cumulative progress in science will probably do more than anything else to determine the shape of our collective future. In order to ensure that we're spending enough—and doing so on the right things and in the right ways (maybe we should have more independent institutes, or more funding of promising early-career scientists, or...)—how should we think about measuring the results? (It's interesting that this question doesn't seem to be analyzed more deeply. For example, the NIH spends about $37 billion per year, and yet there are essent…
    Questions · Patrick Collison
  • Educational psychologist Benjamin Bloom found that one-on-one tutoring using mastery learning led to a two sigma(!) improvement in student performance. The results were replicated. He asks in his paper that identified the "2 Sigma Problem": how do we achieve these results in conditions more practical (i.e., more scalable) than one-to-one tutoring?
    Questions · Patrick Collison
  • Synthetic-morphogenesis: atomically-precise, scalable 3D printing
    GC-Main
  • Reducing diseases via gene drives
    GC-Main
  • microbiome modification for space
    GC-Main
  • Brain-computer interfaces
    Technology some people are excited about
  • A way to tackle this is to study the genetics of mood in the same way that the genetics of supercentenaries are being studied now. The problem is the inherent difficulties in measuring mood.
    Technology some people are excited about
  • AI assisted drug discovery
    Technology some people are excited about
  • Genetic prediction of illness This will greatly decrease the need for some amount of medical insurance, as risks will be known. Parents will be able to know beforehand the likely medical expenses their child will require. But if we are good at this, we will also be good at sequencing these genes out of us.
    Technology some people are excited about
  • Ending aging Artificial wombs
    Technology some people are excited about
  • Cheap AI biometrics / passive diagnosis
    Technology some people are excited about
  • It’s still early, but we’re finally making real progress hacking biology.
    Requests for Startups
  • Recent scientific developments have changed the way we think about producing protein.
    Requests for Startups
  • If we can fix education, we can eventually do everything else on this list.
    Requests for Startups
  • There is a remarkable correlation between the cost of energy and quality of life.
    Requests for Startups
  • Human memory is too volatile.
    Requests for Startups
  • We spend billions of dollars a year researching diseases of aging like cancer and heart disease, but only a tiny fraction of that researching aging itself.
    Requests for Startups
  • Find people with child-like wonder and enthusiasm, and a history of results.
    Advice for ambitious teenagers -
  • Start a notebook. Write down all of your ideas, particularly your questions.
    Advice for ambitious teenagers -
  • Learn to be very skeptical when everyone talks about something as though it is obvious - few things in science are, at their core.
    Advice for ambitious teenagers -
  • Learn to think original thoughts. Nurture your curiosity. Most people don’t know how most things are defined or work, and most of the answers you have been given in this regard start to fall apart when you really poke at them.
    Advice for ambitious teenagers -
  • Learn a lot about fields that speak to you Build something excellent Learn how to manage yourself
    Advice for ambitious teenagers -
  • One reason CS academics teach theory rather than practice is that it saves time on updates. The math doesn’t change, but the syntax of library calls often does.
    Tweets liked by Chris (4/100) (@chrislorck) / Twitter
  • thinking is easy, information architecture is hard
    Tweets liked by Chris (4/100) (@chrislorck) / Twitter
  • "literally" means both "in reality" and "in literature". figures of speech are literary phenomenon. So "literally" literally means figuratively!
    Tweets liked by Chris (4/100) (@chrislorck) / Twitter
  • Have courage. Your taste might not yet be refined, and that’s okay. One of the mistakes I made early on in life is being scared to share what I’m interested in. But how can my taste improve if I never seek out a feedback loop to iterate and refine? So really, be shameless in sharing your taste, and importantly, surround yourself with people who want the best for you — who might make fun of you without being demeaning and force you to improve. It might take a while to find your dinosaurs and wobbling plates, but once you do, chase them relentlessly. Who knows where you end up? You might cure ca…
    Don't try to cure cancer — Ada Nguyen
  • How exactly do you follow your curiosities then? When you first start out, you probably have some propensity towards one thing over another. Dig deeper into it and ask why. Seek out similar and opposite things, give everything a chance at least once, and iterate.
    Don't try to cure cancer — Ada Nguyen
  • Curiosity is like your friend you end up dating. You get to know each other through the years, all the good and the bad. In the end, you chose them because you know you like them for who they are, not because of an unrealistic idealization.
    Don't try to cure cancer — Ada Nguyen
  • Passion is a goal, whereas curiosity is a process.
    Don't try to cure cancer — Ada Nguyen
  • To keep going, you need to find what you are doing fun as well as believe in it. When you follow your curiosity, you naturally find doing things fun. That doesn’t mean that it’s easy, but the motivation driven by curiosity fuels you to work hard. When you have strong conviction in your ideas, you also have the courage to keep going, no matter how contrarian they are. Greatness is a matter of survival, and curiosity helps you stay in the fight.
    Don't try to cure cancer — Ada Nguyen
  • Steve Jobs said of his own life: “You can’t connect the dots looking forward; you can only connect them looking backward. So you have to trust that the dots will somehow connect in your future. You have to trust in something — your gut, destiny, life, karma, whatever.” It’s much easier to believe in your taste and ideas when you know they are your own. And the best way to do so is following your curiosity.
    Don't try to cure cancer — Ada Nguyen
  • Curiosity makes you develop your taste instead of adopting someone else’s. Being curious, playing and messing around is how you discover your taste for things that seem “right” and rewarding. And taste, like everything else, develops with practice. The more you follow your curiosity, the more you develop the intuition for your taste. And when you have that intuition, you trust yourself more.
    Don't try to cure cancer — Ada Nguyen
  • Some might argue that taste might even be the most valuable intellectual tool you can have, because taste dictates what you choose to pursue. It’s important to develop your own taste because paradigm-shifting work itself is contrarian. Both the Theory of Evolution and Theory of Relativity challenged the current paradigm. And they ended up changing everything.
    Don't try to cure cancer — Ada Nguyen
  • It is almost a pattern that paradigm-shifting work is done by people who are purely curious about why things are the way they are. Darwin paid close attention to the finches on Galapagos Island because he was curious about them, not because he knew it would lead him to the Theory of Evolution. Einstein was obsessed with his thought experiment of chasing after a beam of light because it was a puzzle, not because he thought he would develop special relativity. Geniuses did genius-level work because they followed their curiosity, not because they set out to do something great.
    Don't try to cure cancer — Ada Nguyen
  • a lot of things that you think are increasing are probably just things you're becoming aware of
    Tweets liked by Chris (4/100) (@chrislorck) / Twitter
  • “What gets us into trouble is not what we don’t know. It’s what we know for sure that just ain’t so.” –Mark Twain
    Tweets liked by Chris (4/100) (@chrislorck) / Twitter
  • "It’s not the load that breaks you down, it’s the way you carry it." – Lena Horne
    Tweets liked by Chris (4/100) (@chrislorck) / Twitter