Tissue-specific impacts of aging and genetics on gene expression patterns in humans | Nature Communications

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Age is a risk factor for many diseases, but the impact of aging on molecular phenotypes is not fully understood. Here, the authors quantify the relative contributions of genetics and aging to gene expression patterns across 27 tissues in humans, showing that age and genetics each play distinct roles in shaping expression phenotypes.

Download PDF Subjects Evolutionary genetics Gene expression Transcriptomics Abstract Age is the primary risk factor for many common human diseases. Here, we quantify the relative contributions of genetics and aging to gene expression patterns across 27 tissues from 948 humans. We show that the predictive power of expression quantitative trait loci is impacted by age in many tissues. Jointly modelling the contributions of age and genetics to transcript level variation we find expression heritability ( h 2 ) is consistent among tissues while the contribution of aging varies by >20-fold with \({R

Tissue-specific impacts of aging and genetics on gene expression patterns in humans | Nature Communications

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