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The trinity of COVID-19: immunity, inflammation and intervention | Nature Reviews Immunology

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In the short time since SARS-CoV-2 infections emerged in humans, much has been learned about the immunological processes that underlie the clinical manifestation of COVID-19. Here, the authors provide an overview of the pathophysiology of SARS-CoV-2 infection and discuss potential therapeutic approaches.

World Health Organization. WHO Director-General’s opening remarks at the media briefing on COVID-19 - 11 March 2020. WHO https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 (2020). Fehr, A. R. & Perlman, S. Coronaviruses: an overview of their replication and pathogenesis. Methods. Mol. Biol. 1282, 1–23 (2015). Article CAS PubMed PubMed Central Google Scholar Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species severe acute respiratory syndrome-related coronavirus:…

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