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Frontiers | The Intense World Theory – A Unifying Theory of the Neurobiology of Autism

frontiersin.org · 1,106 words · saved by 1 readers

Citation numbers are available from Dimensions Henry Markram, Tania Rinaldi and Kamila Markram Joe Z. Tsien Mônica R. Favre, Deborah La Mendola, Julie Meystre, Dimitri Christodoulou, Melissa J. Cochrane, Henry Markram and Kamila Markram Monica Regina Favre, Tania Rinaldi Barkat, Deborah L Mendola, Georges Khazen, Henry Markram and Kamila Markram Semir Zeki, John Paul Romaya, Dionigi M.T. Benincasa and Michael F Atiyah Autism covers a wide spectrum of disorders for which there are many views, hypotheses and theories. Here we propose a unifying theory of autism, the Intense World Theory. The proposed neuropathology is hyper-functioning of local neural microcircuits, best characterized by hyper-reactivity and hyper-plasticity. Such hyper-functional microcircuits are speculated to become autonomous and memory trapped leading to the core cognitive consequences of hyper-perception, hyper-attention, hyper-memory and hyper-emotionality. The theory is centered on the neocortex and the amygdala,

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