Perspective: Equality need not be painful | Nature

Pain researchers' arguments for using only male rodents in preclinical pain research don't hold up to scrutiny, says Jeffrey S. Mogil.

Download PDF Subjects Neuroscience Policy Pain researchers' arguments for using only male rodents in preclinical pain research don't hold up to scrutiny, says Jeffrey S. Mogil. Credit: Jean-Sebastien Austin Sex differences in pain and analgesia are real and robust. I found this out in graduate school, more or less by accident: a casual reanalysis of data from an experiment performed earlier that day revealed that the drug that my colleagues and I were studying worked completely in the male mice but not at all in the females 1 . I thought that such a glaring yet unexpected difference would whet

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