New Device Detects Brain Waves in Mini Brains Mimicking Early Human Development

The flower-shaped device wraps around brain organoids and maps nearly all electrical activity.

Pea-sized brain blobs are a chatty bunch. Packed with neurons that spark with electrical activity, brain organoids—or “mini brains”—are a now popular way to study the human brain. Some organoids model the brain’s wiring during early development. Others, made from patients’ skin cells, retain DNA mutations that could lead to schizophrenia or autism. Scientists studying mini brains hope to find patterns associated with diseases and test ways to fix them. But it’s harder to record activity in organoids than neurons lying flat in a dish. Traditional electrode arrays are too large and stiff.…

saved by

• Dieter Schoening

related reading

• US20240344014A1 - 3d shell microelectrode arrays for electrically active organoids - Google Patentspatents.google.com
• Understanding the mechanisms of the human brain by building and connecting tissues - Possible Future Case#UTokyo-IISmagazine.iis.u-tokyo.ac.jp
• Ultrasound imaging of the brain — Alephalephneuro.com
• Identification of neural oscillations and epileptiform changes in human brain organoids | bioRxivbiorxiv.org
• Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids | Nature Communicationsnature.com
• Cracking the Neural Code in Humanssimonsfoundation.org
• An underleveraged modality in neuroscience | Abhi Upadhyayaxu.sh
• Reading Minds with Ultrasound: A Less-Invasive Technique to Decode the Brain's Intentionscaltech.edu
• Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloidsnature.com
• The Electrostatic Brain: How a Web of Neurons Generates the World-Simulation that is Youqri.org
• Brain organoid: a 3D technology for investigating cellular composition and interactions in human neurological development and disease models in vitro | Stem Cell Research & Therapy | Springer Nature Linkstemcellres.biomedcentral.com
• Neural Prosthetics - Scholarpediascholarpedia.org