AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks - PMC
The Adverse Outcome Pathway (AOP) framework describes the progression of a toxicity pathway from molecular perturbation to population-level outcome in a series of measurable, mechanistic responses. The controlled, computer-readable vocabulary that defines ...
Toxicol Appl Pharmacol . Author manuscript; available in PMC: 2019 Mar 15. Published in final edited form as: Toxicol Appl Pharmacol. 2018 Feb 14;343:71–83. doi: 10.1016/j.taap.2018.02.006 AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks Maureen E Pittman Maureen E Pittman 1 Oak Ridge Associated Universities, Research Triangle Park, NC 27709, USA Find articles by Maureen E Pittman 1 , Stephen W Edwards Stephen W Edwards 2 US Environmental Protection Agency, Office of Research and Development (ORD), National Health and Environme
related reading
- AOP-helpFinder webserver: a tool for comprehensive analysis of the literature to support adverse outcome pathways development - PMCncbi.nlm.nih.gov
- A curated gene and biological system annotation of adverse outcome pathways related to human health | Scientific Datanature.com
- A weight of evidence assessment approach for adverse outcome pathways - PubMedpubmed.ncbi.nlm.nih.gov
- How can artificial intelligence contribute to explaining biological mechanisms by which an environmental chemical may cause health disorders?network.febs.org
- Gap Mapgap-map.org
- Overview | Human Brain Pharmacomepharmacome.github.io
- Open Targets Platformplatform.opentargets.org
- A primer on why computational predictive toxicology is hardsubstack.com
- Systematic integration of biomedical knowledge prioritizes drugs for repurposinggit.dhimmel.com
- A primer on why computational predictive toxicology is hardowlposting.com
- Discovering genotype-phenotype relationships with machine learning and the Visual Physiology Opsin Database (VPOD) | bioRxivbiorxiv.org
- Request for new ontology pbpkogithub.com