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Indications for valve replacement for high gradient aortic stenosis in adults - UpToDate

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High-gradient aortic stenosis in adults: Indications for valve replacement Author:Patricia A Pellikka, MD, FACC, FAHA, FASE, FESC Section Editors:Catherine M Otto, MDGabriel S Aldea, MD Deputy Editor:Susan B Yeon, MD, JD Literature review current through: Aug 2026. This topic last updated: Oct 07, 2025. INTRODUCTION Aortic valve replacement (AVR) by surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) is the only effective treatment for severe aortic stenosis (AS) [1,2]. Indications for AVR (by SAVR or TAVI) in adults with high-gradient AS are…

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