[] | #2 - by Yufei Xiao - Drops and Clumps
It took us eight weeks of journal club to get through this paper, “Multivalent interactions make adherens junction–cytoskeletal linkage robust during morphogenesis.” There were many counterintuitive answers that challenged my assumptions in the discussions, which made me appreciate the ability of experiments and observations to overthrow old stories (One example being how force and response relate). I was attracted to the definition of robustness in biology. Perhaps most unfounded was my immediate association of the word to how strong a person is to the harshness of life coming their way. The second association comes from networks. Robustness is how many nodes you can randomly remove without collapsing all other nodes and edges. Often, networks that have more edges between nodes are more robust. Additionally, there are often feedback loops which regulate for the network. In this paper, however, the removal, regulation, node, and edge all have more specific connotations. The biological
It took us eight weeks of journal club to get through this paper, “Multivalent interactions make adherens junction–cytoskeletal linkage robust during morphogenesis.” There were many counterintuitive answers that challenged my assumptions in the discussions, which made me appreciate the ability of experiments and observations to overthrow old stories (One example being how force and response relate). I reformatted all the figures in the paper to annotate part by part and organize them in ways that made sense to me. I was attracted to the definition of robustness in biology. Perhaps most…
related reading
- Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton - PMCncbi.nlm.nih.gov
- Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteinsncbi.nlm.nih.gov
- Mechanosensing and Mechanotransduction at Cell–Cell Junctions - PMCncbi.nlm.nih.gov
- Pace Layering: How Complex Systems Learn and Keep Learning · Journal of Design and Sciencejods.mitpress.mit.edu
- Book Review: Design Principles of Biological Circuits — LessWronglesswrong.com
- jsomers.net | I should have loved biologyjsomers.net
- Peifer Labpeiferlab.web.unc.edu
- Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity | Nature Communicationsnature.com
- Peifer Labpeiferlab.web.unc.edu
- Remodeling the zonula adherens in response to tension and the role of afadin in this response - PMCncbi.nlm.nih.gov
- A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension - PMCncbi.nlm.nih.gov
- Publications - Nazockdast Labnazockdastlab.com