CNIH4 Gene - GeneCards
CNIH4 encodes cornichon family member 4, a membrane-associated factor that enables CCR5 chemokine receptor binding activity and participates in endoplasmic reticulum to Golgi vesicle-mediated transport. It belongs to the cornichon family and is annotated as a predicted membrane protein, with expression measurements showing higher levels in the endocrine system, respiratory system, and proximal digestive tract. CNIH4 is localized to the endoplasmic reticulum, the endoplasmic reticulum-Golgi intermediate compartment, the membrane, and COPII-coated ER to Golgi transport vesicles. These localizations fit its role in protein transport and vesicle-mediated transport, placing it in the trafficking route that carries cargo from the endoplasmic reticulum toward the Golgi apparatus. Clinical associations are limited in the provided record, and the strongest functional link is its CCR5 binding activity rather than a named disease relationship. CNIH4 is therefore most directly viewed through its r