Defeating pests with AI models: Our first-principles approach
In this short blogpost, we’ll be expanding upon some of our core technology, and our approach to molecular discovery for pesticides. In general, we view pesticide discovery as a search space problem, where we’re trying to optimize for multiple different (sometimes conflicting) properties of small-molecules and peptides. We believe that foundational models have become powerful tools for predicting these different properties, and hence can be leveraged with generative pipelines to effectively find pesticides. We support this hypothesis by showing in-vitro data for pesticides discovered by our model, targeting Spodoptera Frugiperda, an invasive pest species that causes $10 Billion worth of damages every year. Pesticides are substances used to control and kill pests. The word ‘pests’ is a very broad one, and as such, pesticides is a ‘catch-all’ term for substances that are used to kill insects, control invasive weeds (herbicides). Pesticides are essential for 98% of all farmlands. Good! No
Defeating pests with AI models: Our first-principles approach EN EN English 中 中文 हि हिंदी In this short blog post, we’ll be expanding upon some of our core technology and our approach to molecular discovery for pesticides. In general, we view pesticide discovery as a search space problem, where we’re trying to optimize for multiple different (sometimes conflicting) properties of small molecules and peptides. We believe that foundational models have become powerful tools for predicting these different properties, and hence can be leveraged with generative pipelines to effectively find pesticide
saved by
related reading
- A Conversation With Navvye Anand (Bindwell) | Rowanrowansci.com
- Protein World Model | Biohubbiohub.ai
- Teen founders raise $6M to reinvent pesticides using AI — and convince Paul Graham to join in | TechCrunchtechcrunch.com
- Highly accurate protein structure prediction with AlphaFoldnature.com
- Google DeepMind and Isomorphic Labs introduce AlphaFold 3 AI modelblog.google
- The ML drug discovery startup trying really, really hard to not cheat (Leash Bio)owlposting.com
- AlphaFold2 @ CASP14: “It feels like one’s child has left home.” << Some Thoughts on a Mysterious Universemoalquraishi.wordpress.com
- Practical Cheminformatics Index - Practical Cheminformaticspatwalters.github.io
- Reimagining Drug Discovery Process with AI - Isomorphic Labsisomorphiclabs.com
- AlphaFolddeepmind.google
- nesso1.pdfvalencelabs.com
- Towards the explainability of protein language modelsnature.com