MTHFR: A Supplement Stack Approach : r/MTHFR
The plan is in phases and incrementally ramps up over time, as it is quite common for people to have sensitivities to changes in their methylation status. This plan is also a layered approach: each phase adds in a layer of nutrients/supplements. So, we are building an 'MTHFR stack'. The view I am following for MTHFR is largely derived from that recommended by Chris Masterjohn, but with some differences, and the phases are my design. The result is therefore internet advice from a non-professional, it is general advice and not specific to any individual, and should be treated accordingly. Due to the reductions in methylfolate production, the folate/B12-dependent remethylation pathway is impaired. Therefore, support the choline-dependent remethylation pathway. Optimize the impaired folate/B12-dependent remethylation pathway to make best use of its remaining functionality. Reduce demand on the methylation cycle. Unless you have a specific reason to take them, avoid B complexes. They tend t