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Frontiers | Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

frontiersin.org · 1,106 words · saved by 1 readers

Citation numbers are available from Dimensions Anhembi Morumbi University, Brazil Downstate Health Sciences University, United States Department of Pharmacy, University of Pisa, Italy Sara Dutta, Kelly C. Chang, Kylie A. Beattie, Jiansong Sheng, Phu N. Tran, Wendy W. Wu, Min Wu, David G. Strauss, Thomas Colatsky and Zhihua Li Barbara Wiśniowska, Zofia Tylutki and Sebastian Polak Giulia Chemi, Sandra Gemma, Giuseppe Campiani, Simone Brogi, Stefania Butini and Margherita Brindisi Jaimit Parikh, Paolo Di Achille, James Kozloski and Viatcheslav Gurev Oliver J. Britton, Najah Abi-Gerges, Guy Page, Andre Ghetti, Paul E. Miller and Blanca Rodriguez Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond Early prediction of cardiotoxicity is critical for drug development. Current animal models raise ethical and translational questions, and have limited accuracy in clinical risk prediction. Human-based computer models constitute a fast, cheap and potentially effective alternat

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