Guiding pluripotent stem cell therapies past the immune system | Stem Cells Translational Medicine | Oxford Academic
Hannah A Pizzato, Deepta Bhattacharya, Guiding pluripotent stem cell therapies past the immune system, Stem Cells Translational Medicine, Volume 15, Issue 8, August 2026, szag051, https://doi.org/10.1093/stcltm/szag051 Hannah A Pizzato, Deepta Bhattacharya, Guiding pluripotent stem cell therapies past the immune system, Stem Cells Translational Medicine, Volume 15, Issue 8, August 2026, szag051, https://doi.org/10.1093/stcltm/szag051 Pluripotent stem cell (PSC)-based therapies hold the potential to unlock cures for numerous diseases, including, but not limited to, Parkinson’s disease, macular degeneration, heart failure, type 1 diabetes, and cancer. Yet as protocols to differentiate PSCs into therapeutically useful cell types have progressed rapidly, immunological rejection remains a major barrier that may limit the widespread use of such PSC-based therapies. In recent years, strategies to genetically modify PSCs to prevent immunological rejection of the downstream cell product have