Four Core Genotypes mouse model
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Four Core Genotypes (FCG) mice are laboratory mice produced by genetic engineering that allow biomedical researchers to determine if a sex difference in phenotype is caused by effects of gonadal hormones or sex chromosome genes. The four genotypes include XX and XY mice with ovaries, and XX and XY mice with testes. The comparison of XX and XY mice with the same type of gonad reveals sex differences in phenotypes that are caused by sex chromosome genes. The comparison of mice with different gonads but the same sex chromosomes reveals sex differences in phenotypes that are caused by gonadal hormones.