Protein topology and stability define the space of allowed sequences - PMC

We describe a new approach to explore and quantify the sequence space associated with a given protein structure. A set of sequences are optimized for a given target structure, using all-atom models and a physical energy function. Specificity of the ...

Proc Natl Acad Sci U S A . 2002 Jan 22;99(3):1280–1285. doi: 10.1073/pnas.032405199 Protein topology and stability define the space of allowed sequences Patrice Koehl Patrice Koehl 1 Department of Structural Biology, Fairchild Building, D109, Stanford University, Stanford, CA 94305 Find articles by Patrice Koehl 1, * , Michael Levitt Michael Levitt 1 Department of Structural Biology, Fairchild Building, D109, Stanford University, Stanford, CA 94305 Find articles by Michael Levitt 1 Author information Article notes Copyright and License information 1 Department of Structural Biology, Fairchild

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