News & Events | JAIST

A research team of Prof. Eijiro Miyako at the Japan Advanced Institute of Science and Technology (JAIST) has discovered that the bacterium Ewingella americana, isolated from the intestines of Japanese tree frogs (Dryophytes japonicus), possesses remarkably potent anticancer activity. This groundbreaking research has been published in the international journal Gut Microbes. While the relationship between gut microbiota and cancer has attracted considerable attention in recent years, most approaches have focused on indirect methods such as microbiome modulation or fecal microbiota transplantation. In contrast, this study takes a completely different approach: isolating, culturing, and directly administering individual bacterial strains intravenously to attack tumors--- representing an innovative therapeutic strategy. The research team isolated a total of 45 bacterial strains from the intestines of Japanese tree frogs, Japanese fire belly newts (Cynops pyrrhogaster), and Japanese grass li

News & Events | JAIST News & Events HOME  > ［News & Events］ Gut Bacteria from Amphibians and Reptiles Achieve Complete Tumor Elimination MENU News Awards Press Release Events Press Release Gut Bacteria from Amphibians and Reptiles Achieve Complete Tumor Elimination 【Key Research Achievements】 Demonstration that natural bacteria isolated from amphibian and reptile intestines achieve complete tumor elimination with single administration Combines direct bacterial killing of cancer cells with immune system activation for comprehensive tumor destruction Outperforms existing chemothe

related reading

• Faecal transplants can treat some cancers — but probably won’t ever be widely usednature.com
• Going Founder Mode On Cancer - by Elliot Hershbergcenturyofbio.com
• Antibiotics Modulate Chemotherapy Efficacy in Patients with Esophageal Cancerncbi.nlm.nih.gov
• Cancer cells educate natural killer cells to a metastasis-promoting cell state - PMCpmc.ncbi.nlm.nih.gov
• Cancersytse.com
• Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma modelpmc.ncbi.nlm.nih.gov
• Cancer cells educate natural killer cells to a metastasis-promoting cell state - PubMedpubmed.ncbi.nlm.nih.gov
• Google’s Gemma AI model helps discover new potential cancer therapy pathwayblog.google
• Medical breakthroughs in 2025 - by Saloni Dattaniscientificdiscovery.dev
• Enteromeenterome.com
• A new technique successfully fried up to 75 percent of tumors using ultrasoundinterestingengineering.com
• Why are early-onset colorectal cancer rates spiking?communitymorgue.com