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Activation of Carbonyls - Chemistry LibreTexts

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A secondary theme in carbonyl chemistry centers on the role played by the oxygen lone pairs. A compound with lone pairs can act as a Lewis base. Can carbonyl compounds also act as Lewis bases? The answer is yes, although it is most important to think about carbonyls primarily as Lewis acids.

A secondary theme in carbonyl chemistry centers on the role played by the oxygen lone pairs. A compound with lone pairs can act as a Lewis base. Can carbonyl compounds also act as Lewis bases? The answer is yes, although it is most important to think about carbonyls primarily as Lewis acids. One of the reasons the basicity of the lone pair matters is because of carbonyl activation. If a carbonyl donates a lone pair to a Lewis acid, forming a bond, the carbonyl gets a formal positive charge. If the carbonyl has a formal positive charge, it attracts electrons more strongly. In that case, nucleop

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