Episode 45 – (Trans)locating the bacteria – The Curious Clinicians
Why does cirrhosis predispose to “bacterial translocation”? Spontaneous bacterial peritonitis (SBP) is an infection of ascitic fluid without an intra-abdominal surgically-treatable sour…
Why does cirrhosis predispose to “bacterial translocation”? Spontaneous bacterial peritonitis (SBP) is an infection of ascitic fluid without an intra-abdominal surgically-treatable source (e.g., perforated bowel). Although the spontaneous in SBP might suggest this infection of ascitic fluid pops up out of nowhere it is a multifactorial process. And despite the key role of “bacterial translocation”, this is but one of many key events leading to SBP. In fact, there are at least three relevant factors in cirrhosis that predispose to SBP : Intestinal bacterial overgrowth Increased inte
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