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New tools for programming biology - by Elliot Hershberg

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Welcome to The Century of Biology! This newsletter explores data, companies, and ideas from the frontier of biology. You can subscribe for free to have the next post delivered to your inbox: Subscribed Enjoy! 🧬 In June of 2012, a research paper describing the discovery of CRISPR landed in Science Magazine. In November of 2023, a CRISPR-based cell therapy for blood disorders called Casgevy gained regulatory approval. Taken in context, this is extraordinary. Most new drugs take between ten and fifteen years to make their way onto the market. This is the time estimate for drug modalities that we have many decades of experience developing—biologics and small molecules. Eleven years ago, CRISPR was a purely academic result in bacterial cells. It was a promising result, for sure, but nowhere near a drug. Having evolved as a bacterial immune system against viruses, CRISPR can make programmed breaks in DNA—breaks that happen at a specific sequence in the genome. From the outset, it was clear

New tools for programming biology Continuous mutagenesis, RNA writing, and more Elliot Hershberg Feb 18, 2024 72 10 8 Share Welcome to The Century of Biology! This newsletter explores data, companies, and ideas from the frontier of biology. You can subscribe for free to have the next post delivered to your inbox: Subscribe Enjoy! 🧬 In June of 2012, a research paper describing the discovery of CRISPR landed in Science Magazine . In November of 2023, a CRISPR-based cell therapy for blood disorders called Casgevy gained regulatory approval. Taken in context, this is extraordinary . Most new drug

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